Histoacryl® Flexible Pack

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Improved skin closure

Histoacryl® Flexible is a sterile and liquid topical skin adhesive, consisting of n-butyl-2-cyanoacrylate and a softener. For easy visual assessment of the layer that has been applied, it is coloured blue. 

 

Histoacryl® Flexible may be used with an optional applicator tip intended to provide easy distribution of the adhesive over the wound.

 

Histoacryl® Flexible provides safe and effective skin closure with:

  • a wound dehiscence rate lower than or equal to 4.5% [1]
  • a wound infection rate lower than or equal to 3.9% [1]
  • a wound complication rate lower than or equal to 10.2% [1]

Advantages

  • Flexibility
    Allows closure of incisions up to 25 cm (proven by in-vitro data). [2-4]
  • Microbial barrier
    Act as a physical barrier to microbial penetration as long as the adhesive film remains intact. [5,6]
  • Saves time
    Decreased skin closure time compared to sutures. [7]
  • Less pain
    Less pain than suture materials in skin closure. [8]
  • Reduces recovery time
    Patient recovery time after wound closure is shorter than with subcuticular sutures. [8]
  • Fast and efficient Polymerization
    Only 30 seconds of holding the wound edges together are needed. [1]
  • Ready to use
    Storable at temperature below 25 ºC. [9]

Indication

Histoacryl® Flexible is indicated for the closure of minimum tension skin wounds from clean surgical incisions and simple, thoroughly cleansed, trauma induced lacerations. 

[1] Histoacryl® Flexible Instructions for Use
[2] Report ECT / Dr. Gabriel Siedle / Test of the flexibility of Histoacryl® and Histoacryl® Flexible, November 2012 
[3] Frey-Tox Report / Lab.- Nr. 03145 / Flexible Gewebekleber
[4] RDR/DID/CHM/DCE/16106 – Validation of Histoacryl® Flexible_in vivo study 
[5] Internal Report_MDT medical device testing GmbH report / Project 12m020 / Determination of Microbiological Barrier Properties of Two Topical Skin Adhesives
[6] MDT microbial device testing GmbH report / Project 13m155 / Determination of Microbiological Barrier Properties of Two Topical 
[7] Witting S, Ingwersen M, Lehmann T, Aschenbach R, Eckardt N, Jürgen Zanow, et al. Wound Closure After Port Implantation-A Randomized Controlled Trial Comparing Tissue Adhesive and Intracutaneous Suturing. Dtsch Arztebl Int. 2021;118(44):749-55.
[8] Dasrilsyah RA, Kalok A, Ng BK, Ali A, Teik Chew K, Lim PS. Perineal skin tear repair following vaginal birth; skin adhesive versus conventional suture - a randomised controlled trial. J Obstet Gynaecol. 2021;41(2):242-247. 
[9] RDR/DID/CHM/SLE/20053 – Real Time Stability Study on Histoacryl Flexible – 25 ºC – 60%